Emodin is a derivative of transbase allione, which exists in rhubarb, Polygonum multiflorum, polygonum cuspidatum and so on. It has a wide range of pharmacological effects and has good clinical application value.
Emoin has broad spectrum bacteriostatic effect, not easy to produce drug resistance to staphylococcus aureus, also very sensitive to streptococcus, next to diphtheria, subtilis, anthrax, paratyphus, dysentery, influenza bacilli and pneumococcus and cataracts effective, to anaerobic bacteria have a strong inhibitory effect.
Emodin has an inhibitory effect on hepatitis B virus, cytomegalovirus, EB virus, coronavirus, poliovirus and simplex scareruption virus. The most potent combination for antiviral synthesis is emodin - curcumin - matrine. Emodin can prevent simplex scareruption virus replication by inhibiting the process of virus adsorption and penetration.
Emodin has the function of preventing liver cancer, preventing fatty liver, resisting liver cell fibrosis, inhibiting hepatitis B virus and protecting damaged liver cells. Studies on prevention and treatment of liver cancer have found that emodin has strong inhibitory effect on some liver cancer cell lines. Prevention and Treatment of fatty liver Dong Hui et al. found that emodin has a certain prevention and treatment effect on fatty liver induced by alcohol and high fat feeding in rats. Anti-hepatic fibrosis Hepatic stellate cells are the key cells in the formation of hepatic fibrosis. It was found that the direct inhibition of emodin on the proliferation of hepatic stellate cells and the synthesis of extracellular matrix may be the main mechanism of its anti-hepatic fibrosis. Studies have found that emodin has certain inhibitory effect on hepatitis B virus in vitro. Lin Shengzhang et al. found that emodin has a protective effect on hepatic ischemia-reperfusion injury, which is related to reducing the degree of lipid peroxidation and hepatic sinusoid endothelial cell injury after hepatic ischemia-reperfusion.
Emodin has antioxidant and free radical scavenging effects, and its prevention and treatment effect on atherosclerosis is related to anti-lipid peroxidation. Emodin can obviously increase the activity of superoxide dismutase (SOD), decrease the content of malondialdehyde (MDA) in serum, and increase the activity of Gudiobu ganfu peroxidase. As an effective antioxidant, emodin has obvious effect on restoring the health of periodontal tissue. Anti-cerebral ischemia injury Rhubarb and its extracts can alleviate cerebral tissue injury after cerebral ischemia reperfusion in rats, and have protective effect on cerebral ischemia injury in rats. Li Jiansheng et al. found that emodin's anti-cerebral ischemia mechanism may be realized by inhibiting the inflammatory cascade of brain tissue and increasing the level of brain protective factors such as transforming growth factor.
Emodin can prevent acute myocardial infarction by decreasing the expression of TNF-A and the activity of nuclear factors in the region of myocardial infarction to inhibit inflammation, and by inhibiting the activity of half aspartase 3 to inhibit the necrosis of myocardial cells. Emodin can inhibit atherosclerosis and reduce blood lipid. It was found that emodin and berberine could significantly decrease blood glucose and lipid levels in diabetic rats, and emodin could improve gastrointestinal motility. Low dose of rhein has positive inotropic effect, while high dose of rhein has anti-arrhythmia and myocardial ischemia effect, and its mechanism is bidirectional regulation of intracellular calcium concentration. Lowering blood pressure The incidence of hypertension is on the rise and has become a common and frequently-occurring disease threatening human health. Water and sodium retention is one of the main causes of hypertension. All drugs with diuretic effect have different degrees of antihypertensive effect. Emodin has a certain diuretic effect, so it also has a certain antihypertensive effect.
With the further study of emodin, the good technology of extraction and separation, content determination and clinical application of emodin will gradually appear. Emodin, a widely used natural active ingredient, has a broad prospect of development and application. These methods will also promote the development of plant active ingredients and the modern research of traditional Chinese medicine.
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