How Long Does It Take for Magnesium L-Threonate to Work?

2023-11-09 19:39:30

Magnesium L- threonate is a form of magnesium supplement that can help ameliorate brain function and memory. It differs from other forms of magnesium in its superior capability to cross the blood- brain hedge. As someone interested in cognitive health and performance, I wanted to learn further about this unique magnesium emulsion.

What is Magnesium L-Threonate?

Magnesium L-threonate contains the magnesium ion bonded to a L-threonate molecule. It was specifically developed by experimenters at MIT to deliver magnesium more effectively to the brain( 1). Of the available magnesium supplements on the request, magnesium L- threonate is one of the many that can readily cross the blood- brain hedge( 2).

Studies show it's suitable to increase magnesium situations in the brain further than other forms of magnesium supplements. The L- threonate element is vital for helping transport the magnesium ions across the blood- brain hedge and into the cerebrospinal fluid.

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How Does It Work?

The L- threonate patch basically acts as a carrier to get the magnesium across the blood- brain hedge and into the central nervous system. Once it crosses over, further magnesium is made available to ply its salutary goods on cognitive functions like memory, literacy, and synaptic malleability( 3).

Magnesium plays an important part in regulating NMDA receptors involved in synaptic malleability and long- term potentiation that are important for literacy and memory. With further magnesium available in the brain from the magnesium L- threonate, it may help help neurodegeneration and age- related cognitive decline( 4).

Benefits of Magnesium L-Threonate

There are several promising research studies showing the potential cognitive benefits of supplementing with magnesium L-threonate powder:

- Improves short-term and working memory in both young and aging adults [5].

- Enhances long-term potentiation in the prefrontal cortex through activation of NMDA receptors, which is critical for learning and memory [6].

- Reduces cognitive decline associated with aging in rats by enhancing synaptic density and plasticity [7].

- Considered a potential therapeutic agent for age-related cognitive diseases like Alzheimer's and dementia [8].

- May improve other cognitive abilities like recall, executive function, and attention span [9].

Dosage Recommendations

Most studies investigating magnesium L-threonate use doses ranging from 500-2000 mg elemental magnesium daily. Due to its enhanced absorption, it can exert benefits at lower dosages compared to other forms of magnesium.

As a general guide, it is recommended to start at a lower dosage around 500 mg daily and gradually increase if needed. The daily amount can be divided into 1-2 doses taken with food to minimize potential side effects [10].

Safety and Side Effects

At the recommended dosages, magnesium L-threonate is considered safe and well-tolerated. The most common side effect is loose stools or mild diarrhea at higher doses as excess magnesium has an osmotic effect in the colon.

However, it demonstrates greater tolerability overall compared to other forms of magnesium supplements. It is still advised to avoid co-administration with medications that are known to interact with increased magnesium levels [11].

What is magnesium L Threonate good for?

Grounded on the exploration, magnesium L- threonate appears most promising for supporting brain health and cognitive functions like memory, literacy, superintendent function, and attention. It may also help decelerate age- related cognitive decline. More studies are still needed to determine efficacy for specific conditions.

Is it safe to take magnesium L Threonate daily?

Yes, it is generally considered safe to take magnesium L-threonate daily when adhering to recommended dosages. Those sensitive to magnesium may start with a lower dose taken with food and monitor for side effects like diarrhea. As with any supplement, it's best to consult your physician before starting a new regimen.

What is the difference between magnesium glycinate and magnesium L Threonate?

The key difference is magnesium glycinate provides general magnesium supplementation for the whole body, while magnesium L-threonate is specialized to increase magnesium levels in the brain. Glycinate tends to be used for muscle relaxation, anxiety, sleep and general magnesium repletion. L-threonate is preferred when targeting brain function, memory and neurological health.

Does Magnesium Threonate have any side effects?

The most common side effect of magnesium L-threonate is mild diarrhea or loose stools, especially when taken at higher doses. This occurs as extra magnesium draws more water into the colon. Other digestive upset like nausea, cramping or bloating is possible as well. Too much magnesium can also cause dangerously low blood pressure. Side effects are generally more likely in those with renal impairment.

Does Magnesium Threonate make you sleep?

Some anecdotal reports suggest magnesium L-threonate may help improve sleep quality and duration. However, it does not tend to cause drowsiness or make you sleep, which is more common with forms like magnesium glycinate. The effects on sleep likely come from the increase in brain magnesium levels benefiting neural pathways involved in the sleep-wake cycle. More research is still needed on magnesium L-threonate and sleep.

Does Magnesium Threonate affect sleep?

While magnesium L-threonate is not necessarily used as a sleep aid, some research indicates it may enhance sleep quality in certain groups. One study in older adults with insomnia found it improved sleep efficiency, duration and latency. The mechanisms are not fully clear but likely involve magnesium's role in neurotransmitter pathways involved in sleep regulation. More studies are still needed to confirm effects on sleep.


In summary, Magnesium L Threonate Bulk is arising as a promising magnesium supplement that can effectively cross the blood- brain hedge and deliver cognitive benefits. The exploration looking at memory, literacy, neuroprotection, and age- related cognitive decline is encouraging. While further studies are still demanded, the current substantiation suggests magnesium L- threonate may come a go- to brain health supplement, especially as we progress. As with any new supplement, consult your croaker before taking magnesium L- threonate to make sure it's right for your individual health requirements.

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