Let senescent cells regenerate --- Resveratrol

2023-08-12 09:59:49

As we age, aging cells accumulation and normal functions decline, making us susceptible to diseases. A new British study has found that aging cells can be rejuvenated by a substance found naturally in red wine, dark chocolate, red grapes and blueberries.

This compound is called a resveratrolanalogue. When researchers at the Universities of Exeter and Brighton performed molecular therapy on cells grown in vitro, they found that resveratrol analog activated a gene that encodes splicing factors, allowing the aging cells to regain their youthful characteristics.

So what is resveratrol?

Resveratrol is found in a wide variety of plants,It is a plant antitoxin produced under adverse conditions such as ultraviolet radiation and foreign pathogen invasion. Studies have proved that resveratrol has a variety of beneficial biological effects. Currently, pharmaceutical  companies have developed resveratrol drugs for the treatment of type ii diabetes, with significant effects and broad clinical application prospects.

The first knowledge about resveratrol came from an epidemiological study in France, which found that the incidence of cardiovascular diseases in France was significantly lower than in other countries, and this was related to the higher wine consumption in France. Studies further suggest that resveratrol is one of the key components in wine that plays a role in cardiovascular protection. With the development of research, resveratrol has been found to have a variety of pharmacological activities, such as anti-tumor, lowering blood pressure, anti-platelet aggregation, anti-bacterial and fungal infection, affect gastric acid secretion and so on.

Polygonum cuspidatum is a kind of Chinese herbal medicine commonly used in clinic.It is the dry rhizome and root of the Genus Cuspidatum. At present, there are many reports on the extraction of resveratrol from Polygonum cuspidatum.

What are the pharmacological effects of resveratrol?

Antitumor effect:Among the many pharmacological activities of resveratrol, its anti-tumor effect is the most eye-catching.Resveratrol has significant inhibitory effect on mouse hepatocellular carcinoma, breast cancer, leukemia and other tumor cells. The anti-tumor effect of resveratrol showed that it could inhibit the occurrence, proliferation and development of tumors.

Anti-inflammatory effects:Resveratrol is an inflammatory suppressor that directly inhibits the inflammatory process. In addition, resveratrol inhibits the expression of another pro-inflammatory transcription factor activator protein (AP-1), thereby inhibiting the release of inflammatory factors.

Antioxidation:Chemical structure analysis found that resveratrol contains polyphenol structure, has strong antioxidant effect, can inhibit glutathione disulfide and hydroxyl free radical formation, free radical scavenging, protect DNA from free radical damage.

Protective effects on the cardiovascular system:Resveratrol can effectively inhibit platelet aggregation in the blood circulation and reduce the extent of atherosclerosis and myocardial infarction. Resveratrol can act on vascular smooth muscle, play the role of vasodilator; In vitro studies showed that resveratrol could improve the diastolic function of isolated rat aortic ring. In addition, atherosclerosis and thrombosis can be inhibited through a variety of mechanisms.

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