Resveratrol benefits and contraindications

2023-08-11 20:25:41

What is resveratrol?

Resveratrol is an antiviral secreted by plants and exists in more than 300 edible plants (common: grapes, blueberries, cranberries, peanuts, cocoa, etc.), used to fight trauma, bacteria, infection, ultraviolet rays It can be said to be the patron saint of plants in the face of external environmental pressure.

Resveratrol (Resveratrol) is a kind of polyphenolic antioxidant, which was first isolated from white hellebore by Takaoka in 1940.

Resveratrol is generally divided into cis and trans isomers, but trans is more stable (Trans-resveratrol is the most common in nature), and many effects are only seen in trans (such as regulating inflammatory pathways and anti-proliferation) Therefore, it has become the mainstream of health care ingredients and the main research target.

Most current resveratrol-containing supplements are made from the root extract of the Polygonum cuspidatum plant.

What are the effects of resveratrol?

1. Anti-tumor effect, resveratrol is a natural anti-tumor chemopreventive agent. Cancer cells are inhibited.

2. The protective effect on cardiovascular and cerebrovascular, resveratrol can exert its cardiovascular and cerebrovascular protection by reducing myocardial ischemia-reperfusion injury, inhibiting the formation of atherosclerosis and thrombosis, anti-inflammatory, antioxidant, and vasodilation. effect. Supplementation with resveratrol significantly reduced total cholesterol, systolic blood pressure, and fasting blood sugar.

3. Antioxidant and anti-free radical, resveratrol can scavenge and inhibit the generation of free radicals, inhibit lipid peroxidation, and regulate the activities related to antioxidant enzymes.

4. Regulating the immune system, resveratrol can increase the phagocytosis rate of macrophages in the body. Studies have found that resveratrol also has anti-virus, anti-aging, anti-allergic, liver protection and other effects.

What are the side effects of resveratrol?

Resveratrol is still an emerging health care ingredient, so far, there are still few large-scale human trials, so the exact effective dose and safety concerns (side effects) have not been established.

In a human study (29 days), high daily doses of resveratrol between 2.5 g and 5.0 g were found to produce mild gastrointestinal symptoms (including nausea, flatulence, abdominal discomfort, and diarrhea) (Symptoms appear 2 to 4 days after starting taking, and develop half an hour to 1 hour after ingestion).

5 points of contraindications to the use of resveratrol:

1. Pregnant women, nursing mothers, children, and those with liver and kidney insufficiency should not use it (due to unknown safety)

2. It may have anticoagulant effect, so do not take it together with related anticoagulant drugs, antiplatelet drugs, non-steroidal anti-inflammatory drugs (NSAIDs), common drug names are: aspirin (aspirin), clopidogrel (clopidogrel), diclofenac (diclofenac), ibuprofen (ibuprofen), naproxen (naproxen), dalteparin (dalteparin sodium), enoxaparin (enoxaparin), heparin (heparin), warfarin (warfarin).

3. Resveratrol may interfere with enzymes in the liver related to metabolizing drugs (such as cytochrome P450, CYP1A2), thereby affecting the effects of many common drugs, which may cause unknown risks to those taking the drugs, so it should be avoided in combination with drugs or herbs, or using Consult a qualified doctor or pharmacist beforehand.

4. May have mild estrogenic activity (found in animal studies, not yet proven in human studies), for safety reasons, suffer from estrogen-sensitive diseases (such as breast cancer, ovarian cancer, uterine cancer, endometriosis or uterine fibroids) should be avoided.

5. Stop using resveratrol at least 2 weeks before surgery (due to possible anticoagulant effects)