1. Effect on smooth muscle
The daidzein in pueraria has anti-acetylcholine effect, can significantly contract smooth muscle, and is considered to be the main component of pueraria's antispasmodic effect.
2. The effect on coronary circulation
Pueraria decoction, alcohol extract, total flavonoids and puerarin all have obvious effects of expanding coronary blood vessels, which can increase coronary blood flow and reduce vascular resistance.
3. Effects on myocardial infarction and arrhythmia
Puerarin extract, daidzein and puerarin have obvious anti-arrhythmic effects on aconitine and barium chloride-induced arrhythmia, and puerarin can also significantly shorten the arrhythmia time induced by chloroform and epinephrine in rabbits. Can significantly reduce the scope of myocardial infarction, is considered a β-adrenergic receptor blocker.
4. Effects on cardiac function and myocardial metabolism
Pueraria total flavonoids and puerarin can slow down the heart rate, reduce the total peripheral resistance of the heart, reduce myocardial oxygen consumption; improve myocardial work efficiency. Puerarin can also significantly reduce the production of myocardial lactic acid caused by ischemia, and improve the metabolism of infarcted myocardium.
5. Effects on blood pressure and peripheral blood vessels
Total puerarin and puerarin can significantly reduce plasma renin activity and angiotensin, and blood pressure. Puerarin can significantly improve microcirculation disorders, mainly by increasing the amplitude of microvascular movement and improving local microblood flow; The total flavonoids of puerarin have the effect of significantly dilating cerebral blood vessels, improving cerebral microcirculation and peripheral circulation. It is reported that puerarin can also improve the blocking state of retinal blood vessels, thereby improving visual function.
6. Inhibit platelet aggregation
Puerarin can inhibit adenosine diphosphate (adp)-induced and 5-ht (5-hydroxytryptamine) combined with adp-induced platelet aggregation in humans and animals; in addition, puerarin can also significantly inhibit thrombin-induced platelet aggregation in 5- The release of ht has antithrombotic effect.
7. The effect of lowering blood sugar
Puerarin can resist the blood sugar-raising effect of adrenaline and has a certain blood sugar-lowering ability.
8. The effect on body temperature
The total flavonoids of Pueraria lobata have a lasting and obvious cooling effect on the increase of body temperature caused by endotoxin, and are commonly used in clinical symptoms of exogenous fever.
9. Effects on memory
The total flavonoids and alcoholic extracts of Pueraria lobata can increase the content of acetylcholine in the cerebral cortex and hippocampus of rats, and reduce the activity of acetylcholine transferase in the hippocampus, and fight against the acquired memory impairment of rats affected by scopolamine, which shows that Pueraria lobata has a certain improvement in learning and memory ability.