1.Anti-stomach ulcer effect The components in the aloe extract with a molecular weight in the range of 5,000 to 50,000 contain active ingredients that can inhibit the formation of rat ulcers caused by pyloric ligation and the rat ulcers caused by acetic acid. Further research found that the components with a molecular weight greater than 5000 have anti-ulcer effects on pyloric ligation and acetic acid-induced gastric ulcers in rats, and aloe polysaccharides have obvious inhibitory effects on water-constrained stress ulcers, indomethacin, and ethanol-induced ulcers. When aloin A is administered intravenously at 10 mg/kg, it can inhibit gastric secretion and pepsin activity in pylorus-ligated rats with a dose-dependent relationship. It has a significant inhibitory effect on Shay ulcer and indomethacin-induced gastric injury, and can also significantly Inhibition of water immersion stress gastric injury in pylorus ligated rats.
2. Hepatoprotective effect Aloe injection, total aloe glucosides and total glucoside fractions have protective effects on animals with experimental chemical liver injury, and all three can resist CCl4 and thioacetamide-induced liver injury in mice and galactosamine-induced rats The increase of SGPT caused by liver injury also has different degrees of protection against liver cell damage caused by CCl4.
3. Anticancer effect Anticancer effect Aloe vera extract has inhibitory effect on mouse S180 and Ehrlich ascites cancer. Among them, the high molecular glycoprotein aloin A has obvious anticancer effect in animal experiments. The mechanism is to improve the immune function of the body, increase NK cells, and protect T cells. lymphocytes. The aloe vera alcohol extract and the aloin A and Alomicin isolated from it have anti-tumor effects, and the alcohol extract is effective on metastatic tumors such as Heps, ESC, S180 and B16 melanoma. Intraperitoneal injection of aloin at 50 mg/kg, once a day, for 7 to 10 days, inhibited ESC by 42.9% and S180 by 52.3%. The inhibition rate of Heps was 45.0% after intragastric administration of 50 mg/kg.
4. Protective skin effect Aloe vera extract was injected intraperitoneally into mice at 400mg/kg, and irradiated with 30kvp X-ray after 5min, the protection rate of head skin was 100%, and the protection rate of back skin was 95%. Aloe vera extract also reduced the irritating effect of croton oil on rabbit skin and increased hydroxyproline content in guinea pig skin collagen. Its protective effect is related to scavenging reactive oxygen species, inhibiting lipid peroxides, inducing antioxidant proteins, and preventing DNA and SOD from being damaged.
5. Effects on the immune system Aloe vera extract enhances resistance to Listeria monocytogenes infection in mice. It has a stimulating effect on phagocytes of the reticuloendothelial system. Aloin A has a stimulating effect on DNA synthesis in hamster kidney cells and can activate rat peritoneal macrophages to inhibit the production of PGE2. Intraperitoneal injection of aloin A in rat peritoneal macrophages was more likely to adhere and spread than those without drug treatment, which increased the activity of intracellular β-glucuronidase. A mixture Aa-50 proposed from aloe vera has a stimulating effect on phagocytes and human neutrophils, and a polysaccharide isolated from aloe vera leaves has an immunomodulatory effect and an anti-complement effect.