What is Stigmasterol?

2023-10-19 11:38:26

Stigmasterol is a factory- deduced phytosterol that's structurally analogous to cholesterol. It can be set up in colorful shops including soybeans, legumes, nuts, seeds, whole grains, vegetables, and fruits. This composition explores the chemical parcels, natural sources, and implicit health benefits of stigmasterol, as well as scientific substantiation supporting its efficacity. The focus is on furnishing an overview of our current understanding of this decreasingly studied phytosterol.


Understanding Stigmasterol

Stigmasterol Powder is a steroid alcohol belonging to a family of composites known as phytosterols or factory sterols. Chemically, it's nearly related to cholesterol, differing only in the presence of an fresh double bond in its structure. Like cholesterol, stigmasterol contains a four- ring steroid structure but with an redundant ethyl group at carbon- 24. This subtle difference in chemical structure is enough to conduct stigmasterol with different physical and natural parcels compared to cholesterol.

As a phytosterol, stigmasterol is biosynthesized by shops and plays important functional places analogous to cholesterol in creatures. Structurally, it helps modulate membrane fluidity and permeability in factory cells. It also serves as a precursor patch for the conflation of factory hormones and vitamins like vitaminE. still, stigmasterol isn't synthesized within the mortal body and must be attained simply through salutary sources. Once ingested, it can inhibit cholesterol immersion in the gut, which is the base for its cholesterol- lowering effect.

Natural Sources of Stigmasterol

Stigmasterol is found naturally in a wide variety of plant foods that are important staples of a healthy diet:

Soybeans and Soy Products

Soybeans are one of the richest sources of stigmasterol, providing between 230-500 mg per 100 grams. Soy products like tofu, soy milk, and tempeh are also good sources. The concentration of stigmasterol varies depending on soybean variety, processing method, and geographic origin.

Other Legumes

Legumes like chickpeas, kidney beans, lentils, and peas contain modest amounts of stigmasterol. Peanuts and peanut butter are richer sources, providing approximately 20-55 mg per 100 grams.

Whole Grains

Significant amounts of stigmasterol can be found in unprocessed whole grains and bran. Oats, brown rice, wheat bran and wheat germ offer between 15-50 mg per 100 grams.

Nuts and Seeds

Nuts like almonds, pistachios, and walnuts contain 10-20 mg stigmasterol per 100 grams. Seeds like sesame, pumpkin, sunflower, and flax are also good sources, providing 30-70 mg per 100 grams.

Fruits and Vegetables

Smaller amounts of stigmasterol are found in fruits and vegetables. Good vegetable sources include asparagus, broccoli, spinach, kale and carrots, offering 2-5 mg per 100 grams. Fruits like avocado and papaya also contain modest amounts.

Health Benefits of Stigmasterol

Research suggests that increased dietary intake of stigmasterol may offer a number of potential health benefits:

Cholesterol Lowering Effects

Several studies indicate stigmasterol can lower total cholesterol and" bad" LDL cholesterol situations. It inhibits cholesterol immersion in the bowel by displacing it from micelles needed for immersion. The cholesterol- lowering energy is estimated to be similar to other major phytosterols like beta- sitosterol.

Anti-inflammatory Activity

primary cell studies report stigmasterol possessesanti-inflammatory parcels. It was shown to inhibit the product of certainpro-inflammatory signaling motes and cytokines. This suggests it may help reduce inflammation at the cellular position.

Anticancer Potential

Early test tube and beast studies suggest stigmasterol may inhibit excrescence growth and metastasis of certain cancer cells, including ovarian, bone and colon cancers. The anticancer mechanisms aren't completely understood but may involve converting cancer cell apoptosis and inhibiting angiogenesis. still, further exploration is demanded to confirm these goods in humans.

Cardiovascular Health

The LDL cholesterol lowering action of stigmasterol is believed to support cardiovascular health. Phytosterols may also reduce blood platelet aggregation and improve vascular endothelial function. This indicates potential benefits for heart disease prevention.

Insulin Sensitivity

Rodent studies report stigmasterol may improve insulin sensitivity and reduce hyperglycemia, suggesting benefits for managing diabetes. Proposed mechanisms include enhancing insulin signaling pathways and increasing glucose uptake in muscle and adipose tissue. Human studies are still needed.

Scientific Research and Evidence

Multiple scientific studies have investigated the biological activities and potential health benefits of stigmasterol:

Cholesterol Lowering

Several mortal clinical trials show that diurnal inputs of phytosterol supplements or foods amended with stigmasterol reduce LDL cholesterol situations by 5- 15 in healthy grown-ups and hypercholesterolemic cases. A meta- analysis of 18 clinical trials verified stigmasterol elicits significant cholesterol- lowering goods similar to other major phytosterols like sitosterol.

Anti-inflammatory Activity

In vitro studies demonstrate stigmasterol inhibits product of seditious intercessors like TNF- nascence, IL- 6, iNOS and COX- 2 in actuated macrophages and microglia. It also reduced paw edema swelling in mice, indicatinganti-inflammatory parcels.

Anticancer Effects  

Test tube studies report stigmasterol induces apoptosis and inhibits proliferation, migration, invasion and angiogenesis in gynecologic, colon, liver and breast cancer cell lines. One study showed oral stigmasterol administration inhibited tumor growth in a mouse model of ovarian cancer. More research is warranted to confirm anti-cancer effects in humans.

Overall, the cholesterol-lowering properties of stigmasterol appear well-supported by research. Evidence for other benefits is preliminary but promising. Further human clinical trials are needed to validate the emerging health benefits of this phytosterol.

Safe Dosage and Precautions

There's presently no established salutary reference input for stigmasterol. Supplemental boluses used in studies showing cholesterol- lowering goods range from0.6- 3 grams per day. Advanced inputs above 3 grams per day don't appear to confer fresh benefit.

Stigmasterol is generally recognized as safe and well-tolerated based on its long history of dietary use. Mild side effects reported with high supplemental doses include gastrointestinal symptoms like bloating and diarrhea. Stigmasterol may interact with certain medications including statins, ezetimibe and warfarin, so caution is advised.

People with sitosterolemia, a rare inheritable condition that impairs phytosterol metabolism, should avoid stigmasterol supplementation due to increased threat of atherosclerosis. Pregnant and nursing women should exercise caution until further safety data is available.

Comparison with Other Phytosterols

Stigmasterol belongs to a broader class of plant sterols known as phytosterols. Other common phytosterols include beta-sitosterol, campesterol, and brassicasterol. Like stigmasterol, they have cholesterol-like chemical structures but differ in side chain composition.

Beta-sitosterol is the most abundant dietary phytosterol, followed by campesterol. All phytosterols share similar cholesterol-lowering properties by limiting intestinal absorption. However, early evidence suggests stigmasterol may offer slightly greater anti-inflammatory and anticancer effects compared to beta-sitosterol and campesterol. Ongoing research is elucidating the unique bioactivities of the various phytosterols.

What is stigmasterol used for?

Stigmasterol has no direct medical or commercial applications, but it is nutritionally important as a cholesterol-lowering phytosterol. Dietary stigmasterol is incorporated into plant-based foods, supplements, and sterol-enriched functional foods to help reduce LDL cholesterol. It is also increasingly used as a chemical marker to detect adulteration of olive oils.

Is stigmasterol good for you?

Yes, research suggests stigmasterol may be good for you as part of a healthy diet. It can help lower LDL cholesterol, which supports cardiovascular health. Emerging evidence indicates stigmasterol also has anti-inflammatory and anticancer properties that could benefit health. Foods rich in stigmasterol like soy, nuts, seeds and whole grains are already considered nutritious. Consumption of these foods naturally provides stigmasterol.

What is stigmasterol and campesterol?

Stigmasterol and campesterol are both plant-derived phytosterols that are chemically similar to cholesterol. The key difference is campesterol has an extra methyl group at carbon-24 in its chemical structure. Both are abundant in plant foods and have been shown to lower cholesterol levels. However, preliminary evidence suggests stigmasterol may offer additional anti-inflammatory and anticancer benefits that have not been observed with campesterol.

What is the molecule stigmasterol?

Stigmasterol powder is a plant steroid alcohol molecule belonging to the broader class of phytosterols. Its chemical formula is C29H48O. The four-ring steroid structure is the same as cholesterol, but stigmasterol has extra ethyl and double bonds that alter its shape and properties. This molecule is synthesized in plants and serves multiple functions including membrane stability and hormone precursors. It has cholesterol-like properties but is distinct from cholesterol found in animals.

Is stigmasterol anticancer?

Some primary exploration indicates stigmasterol may have anticancer goods. Test tube and beast studies have shown stigmasterol can suppress excrescence growth, induce apoptosis, and inhibit metastasis in certain cancer cell types including ovarian, bone, colon and liver cancers. The mechanisms aren't completely understood but may involve inhibiting angiogenesis and modulating cancer cell signaling pathways. further exploration in humans is demanded to confirm if stigmasterol has clinically applicable anticancer goods that could be salutary for cancer remedy or forestallment. At this point, the current substantiation remains limited.

What is the solvent for stigmasterol?

Some common solvents used for extracting stigmasterol from plant sources in research studies include:

- Ethanol/Methanol mixtures

- Chloroform

- Hexane

- Acetone

- Ethyl acetate

- Diethyl ether

Stigmasterol has low solubility in pure water but dissolves well in organic solvents. Ethanol and acetone mixtures allow effective extraction from sterol-rich plant materials. Solvent extraction methods can isolate stigmasterol and other phytosterols from their natural sources for analytical testing and bioactivity assessments.


Stigmasterol is an increasingly studied plant phytosterol that shares similarities with cholesterol but has some distinct chemical properties and health benefits. It's set up naturally in soybeans, legumes, whole grains, nuts, seeds and numerous fruits and vegetables. exploration shows stigmasterol can lower LDL cholesterol situations at boluses of0.6- 3 grams per day. Arising substantiation suggests it also hasanti-inflammatory and anticancer goods that bear farther confirmation through mortal trials. Overall, salutary input of stigmasterol-rich factory foods appears to promote cardiovascular health and give other benefits as part of a nutritional diet. Ongoing exploration will continue to uncover the remedial eventuality of this protean factory emulsion.

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