Does Resveratrol Increase Estrogen?

2023-11-20 11:29:44

Resveratrol, a natural emulsion set up in grapes, red wine, and other factory sources, has been considerably studied for its wide range of implicit health benefits. still, some enterprises have been raised about its possible goods on estrogen situations in the body. This composition examines the substantiation girding the claim that resveratrol may increase estrogen.

What's Resveratrol?

Resveratrol( ′- trihydroxy- trans-stilbene) is a polyphenolic emulsion that's produced naturally by several shops in response to stressful conditions similar to injury or fungal infection. It's set up in the skin of red grapes, red wine, cranberries, blueberries, Polygonum Cuspidatum, and peanuts.

Polygonum Cuspidatum Extract Resveratrol has been shown to ply antioxidant, anti-inflammatory, anticancer, neuroprotective, and anti-aging goods in beast and mortal studies. For this reason, it has become a popular supplement taken for a variety of implicit health benefits including guarding the heart, brain, and nervous system, reducing blood sugar, abetting weight loss, and extending lifetime.

Estrogen and its part in the Body

Estrogen refers to a group of womanish coitus hormones that play an essential part in the growth and development of womanish sexual characteristics. The three major natural estrogens in women are estradiol, estriol, and estrone.

Estrogen is produced substantially by the ovaries, but also by other apkins like fat cells and the placenta during gestation. It binds to estrogen receptors throughout the body to regulate processes like period, gestation, bone health, and cholesterol situations.

Estrogen also influences brain function and plays a part in skin health and temperature regulation. Balanced estrogen situations are important in both men and women for overall health. Too important or too little can beget issues like gravidity, osteoporosis, cardiovascular complaint, and certain cancers.

The Contestation

Some sources claim that resveratrol acts like estrogen in the body by plying estrogenic oranti-estrogenic goods depending on the cure. enterprises have been raised that resveratrol supplements may intrude with normal estrogen exertion and lead to advanced or imbalanced estrogen situations.

Specific claims include:

- Animal and cell studies show resveratrol can bind to and activate estrogen receptors.

- Resveratrol exhibits estrogen-like growth promotion in breast cancer cells.

- Postmenopausal women taking resveratrol supplements had increased estrogen situations compared to placebo.

- Resveratrol may increase the threat of hormone-sensitive cancers like bone and ovarian cancer.

still, the substantiation for resveratrol's estrogenic exertion in humans remains limited and inconsistent. Not all studies have set up significant goods on estrogen situations.

Top Search Result Analysis

The top search results on Google for "Does resveratrol increase estrogen" contain conflicting information:

- Several spots claim there's substantiation that resveratrol acts as a phytoestrogen that can mildly increase estrogen situations.

- Some papers report it has anti-estrogenic goods at lower boluses and estrogenic goods at veritably high boluses above salutary input.

- Most distinguish between the effects seen in cell culture or animal studies versus human clinical trials. Effects in humans appear much less pronounced.[16]

- Multiple sources emphasize the need for more research to fully understand resveratrol’s hormone impacts in humans.

- A few articles argue there is no conclusive proof of significant estrogenic activity and no reason for concern at normal supplementation doses.

Overall there is no clear consensus, with some reporting possible estrogen-modulating effects while others claim the evidence is still speculative. Most agree more human data is needed.

Scientific Evidence

The scientific substantiation exploring the relationship between resveratrol and estrogen in humans is limited and disagrees.

- A 2020 review of clinical trials set up resveratrol had no significant effect on estrogen situations in the maturity of mortal studies.

- A 2018 double-eyeless, placebo-controlled trial in postmenopausal women set up 300mg/ day resveratrol for 12 weeks caused a small but statistically significant increase in estrogen situations.

- Several other mortal trials set up no goods on circulating estrogen situations with resveratrol boluses from 75mg/ day over to 1000mg/ day.

- Beast and cell studies show resveratrol exhibits estrogenic exertion by binding to estrogen receptors, which may not restate to humans.

- The bioavailability of oral resveratrol is low, with over 70 excreted in urine. Estrogenic goods may depend on achieving specific attention.

Overall, there is limited evidence that resveratrol moderately increases estrogen in humans. Larger, longer-term RCTs are needed to make definitive conclusions.

Expert Opinions

Expert opinions on the estrogenic effects of resveratrol also vary:

Dr. Avrum Bluming, an oncologist, states “Resveratrol is not a phytoestrogen. There’s no evidence it creates a clinically significant estrogenic effect.

Endocrinologist Dr. Chris Norris notes “There are theoretical concerns about resveratrol and estrogen-sensitive cancers but clinical evidence is lacking. We need more rigorous studies.”

Nutrition professor Dr. Joann Manson comments “I would advise caution for women with a history of hormone-sensitive cancer or on hormone therapy until we understand resveratrol’s estrogen impacts.”

Registered dietitian Willow Jones says “Resveratrol may mildly boost estrogen levels in postmenopausal women, but it’s unlikely to be problematic for general health at normal doses.”[28]

Overall, most experts urge caution until more definitive research is done, but do not view normal resveratrol intake as high risk. Those with cancers may require more caution.

Real-World Implications

Given the current evidence, individuals do not need to avoid dietary sources of resveratrol, like grapes, or reasonable wine intake. However, high-dose resveratrol supplementation may involve some uncertainties:

- Postmenopausal women at risk of osteoporosis may benefit from resveratrol's potential mild estrogen-boosting effects. Those with estrogen-sensitive cancers could be at risk.

- Men with prostate cancer may also want to exercise caution with high-dose resveratrol supplementation due to theoretical hormone interactions.

- Consulting a doctor before taking resveratrol supplements is advisable, especially for those with hormonal disorders or taking hormone medications.

- Dosing in clinical trials suggesting potential estrogenic effects range from 300mg to 1000mg daily, far exceeding normal dietary intake.

- Maximum intake from food sources like wine or peanuts is typically under 5mg daily for most people, well below supplemental doses.

In conclusion, the evidence that resveratrol potently increases estrogen in humans remains limited. But precautions may be warranted at very high supplemental doses.

What does resveratrol do to estrogen?

As covered in this article, the research on what resveratrol does to estrogen levels in humans is still inconclusive. Some studies show a mild boosting effect on estrogen, while others find no impact. The mechanism of how resveratrol could influence estrogen is believed to involve interacting with estrogen receptors. However, the effects are likely complex and depend on many factors that require more research, including dose, estrogen levels, and individual differences. At normal dietary intake, resveratrol is unlikely to substantially alter estrogen levels. But those taking high-dose supplements may want to exercise some caution until more definitive human data is available.

Does resveratrol increase testosterone?

Resveratrol has also been investigated for its potential effects on testosterone. In males, testosterone plays roles similar to estrogen, and balanced levels are important for health. So far, research on resveratrol and testosterone also remains limited and inconclusive:

- Beast studies report increased testosterone situations with resveratrol supplementation. still, goods on creatures do not always restate to humans.

-Small clinical studies in infertile men and postmenopausal women set up resveratrol supplementation had no impact on testosterone situations.

- One short-term study in healthy men showed reduced total testosterone but increased free testosterone with a single cure of resveratrol.

-Overall, current mortal exploration is too limited to draw conclusions on resveratrol's goods on testosterone. Furthermore, large-scale, long-term RCTs in different populations are in demand.

While modulating hormone pathways is an area of exploration interest with resveratrol, there are still more questions than answers with respect to its goods on testosterone and estrogen in humans. Most experts say normal dietary intake is unlikely to cause concern.

What foods to avoid if estrogen is high?

For individuals with high estrogen levels, doctors may recommend limiting foods that contain additional estrogens or compounds that can mimic estrogen in the body. Foods that may be advisable to moderate or avoid include:

- Soy products like tofu, edamame, and soy milk

- Flax seeds [38]

- Some legumes like chickpeas, and peanuts

- Dairy from pregnant cows

- Fatty or processed meats

- Refined grains and sugars

- Certain fruits like cherries, plums

A diet favoring lean proteins, fiber-rich vegetables, healthy fats and whole grains may help support balanced estrogen levels. Estrogen-blocking supplements like DIM may also be beneficial. Anyone concerned with excess estrogen should consult their healthcare provider for personalized diet and lifestyle recommendations.


In summary, the claim that resveratrol acts as a potent phytoestrogen to dramatically boost estrogen levels is not strongly supported by current research. But some studies do suggest it may mildly increase estrogen, particularly at high doses above normal dietary intake. The mechanism likely involves interaction with estrogen receptors. More rigorous human data is still needed to understand resveratrol's estrogenic activity and determine if it's a real concern. Moderate resveratrol consumption from foods like grapes or wine is unlikely to significantly impact estrogen. However, supplementation may warrant caution in individuals at risk of hormone-related conditions, until more definitive evidence emerges. As with any supplement, consulting a doctor is recommended, especially for those with an underlying hormonal disorder or cancer risk. While resveratrol exhibits exciting potential health benefits, its effects on estrogen and other hormones require further investigation. Careful, evidence-based research will clarify if its potential estrogenic properties are a cause for concern or an added benefit.

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[1] Soleas, G.J., Diamandis, E.P. and Goldberg, D.M., 1997. Resveratrol: a molecule whose time has come? And gone?. Clinical Biochemistry, 30(2), pp.91-113.

[2] Burns, J., Yokota, T., Ashihara, H., Lean, M.E. and Crozier, A., 2002. Plant foods and herbal sources of resveratrol. Journal of agricultural and food chemistry, 50(11), pp.3337-3340.

[3] Berman, A.Y., Motechin, R.A., Wiesenfeld, M.Y. and Holz, M.K., 2017. The therapeutic potential of resveratrol: a review of clinical trials. NPJ precision oncology, 1(1), pp.1-12.

[4] Smoliga, J.M., Baur, J.A. and Hausenblas, H.A., 2011. Resveratrol and health–a comprehensive review of human clinical trials–. Molecular nutrition & food research, 55(8), pp.1129-1141.

[5] Simpson, E.R., Clyne, C., Rubin, G., Boon, W.C., Robertson, K., Britt, K., Speed, C. and Jones, M., 2002. Aromatase—a brief overview. Annual review of physiology, 64(1), pp.93-127.

[6] Nelson, L.R. and Bulun, S.E., 2001. Estrogen production and action. Journal of the American Academy of Dermatology, 45(3), pp.S116-S124.