What Does Resveratrol Do for Skin?

2023-11-17 16:28:29

Taking care of our skin is an important part of overall health and beauty. Exposure to sun, pollution, and the natural aging process can all lead to issues like wrinkles, dark spots, emptiness, and loss of elasticity over time.Chancing ways to keep our skin looking immature and radiant as we age is a precedence for numerous. This has led to growing interest in the antioxidant resveratrol as a implicit skin treatment.

Resveratrol is a polyphenolic emulsion naturally set up in some factory sources that has promising goods on skin health. In this composition, we ’ll explore what resveratrol is, where it comes from, how it can benefit the skin, the wisdom behind its use, and how to incorporate it into your routine. Read on to learn if resveratrol might be right for your skincare needs!

Understanding Resveratrol

Polygonum Cuspidatum Extract Resveratrol(3,5,4’-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and an antioxidant produced by several plants in response to stress, injury, fungal infections, or UV radiation exposure. It acts as part of the plant’s defense system.

The skin of red and purple grapes, blueberries, raspberries, and mulberries contain relatively high amounts. Japanese knotweed is another potent source. Resveratrol is also found in peanuts, cocoa, and red wine. The concentration varies widely depending on the plant’s genetics, geographical origin, and growth conditions.

This emulsion has been considerably delved in recent times for its different health benefits. In addition to its antioxidant goods, studies show resveratrol hasanti-inflammatory,anti-aging,anti-cancer, cardioprotective, and neuroprotective parcels.Topical application aims to harness its antioxidant power to protect and rejuvenate skin.

The Impact of Resveratrol on Skin Health

When applied to the skin, resveratrol offers several advantages:

Anti-Aging Effects

One of the crucial benefits of resveratrol is its capability to offset some of the age- related changes in skin physiology. exploration indicates it stimulates collagen and hyaluronic acid product, which reduces wrinkles, boosts pliantness, and enhances hydration and plumpness.( 1)

By adding situations of antioxidant enzymes like superoxide dismutase in skin cells, resveratrol neutralizes oxidative damage from UV exposure that would else break down collagen.( 2)

This helps preserve youthful skin structure.

Protection Against Environmental Damage

In addition to defending against UV damage, resveratrol limits inflammation induced by air pollution and other environmental assaults. When skin tissue becomes inflamed, enzymes called matrix metalloproteinases are activated that degrade collagen. Resveratrol powerfully suppresses these destructive enzymes. [3]

Its antioxidant effects help prevent free radical formation and reduce markers of oxidative stress that drive skin aging. This shields skin from premature wrinkling and hyperpigmentation.

Promoting Skin Regeneration

Applying resveratrol appears to stimulate the proliferation and renewal of skin cells in the epidermis. This speeds healing and recovery from damage. [4] The skin regeneration effects of resveratrol result in smoother, healthier skin over time.

Scientific Evidence and Studies

A growing body of research, including cell studies, animal models, and human clinical trials, supports using resveratrol as a topical skin treatment:

Key Research Findings

- Mice fed resveratrol showed increased skin elasticity, hydration, and collagen density versus controls. [5]

- In a human trial, resveratrol cream reduced wrinkles, epidermal thickness, and skin elasticity after 60 days compared to placebo. [6]

- Multiple studies confirm resveratrol protects fibroblasts and keratinocytes – the main cell types in skin tissue – from oxidative damage. [7]

- Skin cell studies indicate resveratrol accelerates wound healing by stimulating faster migration of skin cells to the wound site, proliferation, and creation of granulation tissue. [8]

Notable Studies on Resveratrol and Skin

A landmark 2007 study found topical resveratrol cream reduced the appearance of wrinkles and protected mitochondrial DNA in skin cells from UVB damage. [9]

A trial in middle-aged women showed four weeks of resveratrol lotion (0.07%) significantly increased hydration, elasticity, and radiance of facial skin versus placebo lotion. [10]

Limitations and Conflicting Results

While research clearly demonstrates resveratrol has beneficial effects on skin cells and animal models, few large scale human studies have been done to confirm efficacy. The optimal dosage and formulation for skin delivery are still being explored.

One study found a lower dose (0.003%) resveratrol cream actually increased UVB damage to skin cells, although higher concentrations were protective. [11] This highlights the need for more trials to find the ideal dosage range.

Incorporating Resveratrol into Skincare

Given the promising research, how can you take advantage of resveratrol’s benefits? Here are some tips:

Available Skincare Products

Many brands now include resveratrol in anti-aging creams, serums, lotions and oils. Look for products listing it as an active ingredient. Concentrations typically range from 0.03% to 1%. Using a resveratrol skin serum daily is an easy way to see results.

Recommended Usage

Apply resveratrol products twice daily after cleansing skin. Gently massage the cream or serum into the face, neck, chest, and other desired areas until fully absorbed. For maximum skin benefits, use resveratrol consistently over an extended period.


Resveratrol is generally well-tolerated, even with long-term use. However those with skin sensitivities should still patch test products first. Avoid applying resveratrol creams to broken or damaged skin. Discontinue use if any irritation develops.

While resveratrol is deemed safe during pregnancy, always consult your doctor first if expecting. There is limited data on using resveratrol regularly on babies and young children, so caution is advised.

Is Resveratrol Better Than Retinol?

Resveratrol and retinol, a vitamin A derivative, are both popular anti-aging ingredients. But they work differently. Retinol stimulates collagen production by increasing skin cell turnover. It is photosensitizing and irritating for some. Resveratrol acts as an antioxidant and anti-inflammatory. It appears gentler than retinol.  

Combining resveratrol with retinol allows using lower, better tolerated doses of retinol, while still boosting collagen and fighting free radical damage. This combined approach may offer greater anti-aging benefits with less risk of dryness, peeling or sun sensitivity caused by retinol alone. [12]

For those unable to tolerate retinol, resveratrol offers a natural antioxidant alternative to fight aging without harsh side effects. Each have unique advantages that make them useful additions to a skin health regimen.

Is Resveratrol or Vitamin C Better for Skin?

Resveratrol and vitamin C (ascorbic acid) are both potent antioxidants valued in skincare. Vitamin C promotes collagen production, brightens skin tone, and neutralizes free radicals that accelerate aging. Resveratrol also protects and regenerates skin through its antioxidant, anti-inflammatory effects.

Studies indicate combining vitamin C and resveratrol provides greater antioxidant protection than either alone. Vitamin C regenerates oxidized resveratrol, allowing it to mop up free radicals again. In turn, resveratrol stabilizes vitamin C, increasing its potency. [13] This synergistic interaction offers superior defense against oxidative damage driving premature skin aging.

For most anti-aging and skin rejuvenation benefits, the evidence supports using both resveratrol and vitamin C topicals as part of a comprehensive regimen.

What Should Not Be Used With Resveratrol?

No specific ingredients are conclusively prohibited for co-use with resveratrol. However, caution may be warranted with:

- Blood thinning medications: Resveratrol may increase risk of bruising and bleeding when combined with warfarin, heparin or anti-platelet drugs like aspirin due to amplified anti-platelet effects. [14]

- Potent CYP3A4 inhibitors: Medications like ketoconazole and itraconazole used to treat infections may affect metabolism and clearance of resveratrol. [15]

- Immunosuppressants: Resveratrol can enhance immune function, possibly interfering with drugs that suppress the immune system after organ transplants. [16]

Always consult your dermatologist before using new skin actives like resveratrol if you take any oral medications or have underlying health conditions. This helps avoid possible contraindications.

Can I Mix Resveratrol with Niacinamide?

Niacinamide( vitamin B3) is another popular skincare component that reduces inflammation, evens skin tone, and boosts hydration and pliantness. Studies indicate niacinamide and resveratrol work synergistically to cover skin cells from oxidative damage that causes aging.

Applying niacinamide and resveratrol together offers superior antioxidant power from two sources. This amplifies their individual goods on wrinkle reduction, hyperpigmentation, sun damage, and collagen breakdown. Both constituents are well- permitted and doubtful to beget issues when combined.

Can You Mix Vitamin C and Resveratrol?

As mentioned before, exploration easily demonstrates vitamin C and resveratrol complement each other for more potent antioxidant goods in skin towel. Vitamin C enhances the bioavailability and efficacity of resveratrol, while resveratrol stabilizes vitamin C to protract its energy.[13]

Using vitamin C and resveratrol together in skincare products or layering separate serums is an excellentanti-aging strategy. Try applying your vitamin C serum first to maximize immersion, followed by a resveratrol- grounded moisturizer or treatment. This dual approach gives your skin an extra shield against oxidative damage to stay looking youthful.


Resveratrol is an emotional antioxidant emulsion that shows real pledge for perfecting colorful signs of skin aging. By stimulating collagen and hyaluronic acid, reducing oxidative damage, inflammation, and precluding declination of the extracellular matrix, resveratrol helps skin stay supple, radiant, and immature. While further clinical studies are still demanded, current substantiation and anecdotal reports suggest resveratrol is a salutary addition to any skincare routine aimed at precluding wrinkles and maintaining healthy, vibrant skin as we progress.

Hubei Sanxin Biotechnology Co., Ltd. integrates the research and development, production and sales for many years. We are your reliable Polygonum Cuspidatum Extract Resveratrol wholesaler. We can supply customized service as your request.

Email: nancy@sanxinbio.com


[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751024/

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751024/

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/

[5] https://pubmed.ncbi.nlm.nih.gov/20620757/

[6] https://onlinelibrary.wiley.com/doi/10.1111/j.1468-2494.2012.00739_2.x

[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751024/

[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/