Kudingchabelongs to the Holly family and is the leaf of the Holly plant. Born in hillside, bamboo forest, shrubbery, distributed in the lower reaches of the Yangtze River provinces and Fujian, is a traditional natural health drink in China. Kudingcha contains more than 200 kinds of ingredients such as butyronin, amino acid, vitamin C, polyphenols, flavonoids, caffeine and protein. The finished tea tastes bitter and sweet and cool. It has the functions of clearing heat and dispelling summer heat, improving eyesight and intelligence, producing fluid and quenching thirst, diuresis and strengthening heart, moistening throat and relieving cough, lowering blood pressure and losing weight, preventing cancer and preventing cancer, delaying aging and activating blood vessels. It has been known as "health care tea" and "beauty tea".

Pharmacological effects of the extraction of Kudingcha

1. Cardiovascular and cerebrovascular function. The results showed that the extract of Kuding tea could significantly increase the coronary flow of isolated guinea pig heart, and the dose of 0.1g could increase 18% (P< 0.01); The survival time of hypoxic mice was increased by 24% (P< 0.05) and the effect increased with the increase of dose; It has obvious protective effect on acute myocardial ischemia induced by pituitrin in rats, and is beneficial to prevention and cure coronary heart disease and relieve the attack of angina pectoris. It can also increase cerebral blood flow, reduce cerebrovascular resistance and blood pressure in anesthetized rabbits, suggesting that the drug has a certain dilating effect on cerebrovascular, which has a certain effect on promoting cerebral circulation, adjusting cerebrovascular function and preventing and treating cerebrovascular diseases.

2. Antihypertensive effect: the antihypertensive effect of the extract of Wintersweet tea leaves was studied. The results showed that the extract of wintersweet tea leaves had obvious antihypertensive effect on two kidney, one clamp hypertensive rats and spontaneous hypertensive rats by intravenous injection, indicating that the drug is expected to be developed as a new antihypertensive drug. 35 cases of hypertension were treated with Kudingcha Holly. After 2 months observation, 2 cases of obvious hypotension, 18 cases of moderate hypotension, 10 cases of mild hypotension and 5 cases of no change were observed. The total effective rate was 95.71%, and the curative effect mechanism was that the extract of Kudingcha could increase.

3.Antioxidant Effect. Recent studies have shown that aging is related to the accumulation of lipid peroxides in the body, and effective elimination, reduction of lipid peroxides in plasma and delay of lipid peroxidation have become one of the current anti-aging approaches. It was found that the extract of Kudingcha had a strong anti-lipid peroxidation effect on rat liver tissue in vitro. It showed a dose-effect relationship in a certain range, and suggested that the extract had a medical effect on inflammation, prevention of cardiovascular and cerebrovascular diseases, cancer prevention and anti-aging and other health care effects.

4. Immune regulation. Ursolic acid contains a large number of lipid soluble components in Kudingcha Ilex, Ilex daye and Citrate, and it has been proved by previous studies that ursolic acid has many biological effects such as sedation, anti-inflammatory, antibacterial, anti-diabetes, anti-ulcer and lowering blood sugar. Ursolic acid has been found to be a good immune enhancer and a new type of anticancer drug with low toxicity and effective antigenicity. Quercetin and hyperoside are also contained in the leaves of citrate citrate. Their pharmacological effects have been reported in many literatures, and they have strong activities of analgesia, enhancing blood flow in brain tissue and anti-ischemic brain injury.

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