What is Chenodeoxycholic Acid
Chenodeoxycholic acid (CDCA) is one of the major bile acids produced in the liver and plays important roles in fat digestion and cholesterol homeostasis. As a supplemental bile acid, CDCA provides benefits for optimizing fat absorption and promoting a healthy balance of gut bacteria.
Bile acids like CDCA are synthesized in the liver from cholesterol. They function as natural detergents that emulsify and solubilize fats, allowing them to be absorbed efficiently during digestion. CDCA specifically accounts for about 30-40% of bile acids.
In addition to aiding fat digestion, CDCA helps regulate cholesterol levels by inhibiting HMG-CoA reductase, a key enzyme in cholesterol synthesis . It also promotes bile flow to eliminate cholesterol from the body.
Chenodeoxycholic Acid Powder helps maintain a healthy gut microbiome balance. It inhibits growth of harmful bacteria while allowing beneficial bacteria like Lactobacillus and Bifidobacteria species to thrive.
CDCA production tends to decline with age. Supplementing with high-quality CDCA improves fat digestion and absorption while supporting healthy cholesterol levels and gut bacteria composition .
347.857 °C/760 mmHg (lit.)
In water: 19.7 mg/L
Pharmaceutical raw materials, Biochemical reagent, Organic raw materials, Organic intermediates
Biochemical research; used to synthesize ursodeoxycholic acid; gallstone dissolving agent, used for calculus, cholecystitis and cholecystitis caused by high cholesterol.
The key evidence-based functions of supplemental CDCA include:
1. Improves Fat Digestion and Absorption
By emulsifying fats, CDCA improves the breakdown and absorption of fat-soluble vitamins A, D, E and K. This provides better nutritional status.
2. Promotes Cardiovascular Health
CDCA inhibits cholesterol synthesis and increases bile flow to eliminate cholesterol from the body. This maintains healthy cholesterol levels already in the normal range.
3. Supports Gut Bacteria Balance
CDCA selectively allows growth of beneficial gut bacteria. This improves the integrity of gut barrier function.
4. Eases Constipation
By increasing bile flow, CDCA helps improve regularity and ease occasional constipation.
5. Protects Liver Function
CDCA has been shown to protect liver cells by reducing inflammation and oxidative stress within the liver.
6. Manages Metabolic Syndrome
By improving cholesterol levels and insulin sensitivity, CDCA may help manage markers of metabolic syndrome like high blood lipids and blood glucose.
7. Aids Weight Management
CDCA supplementation has been shown to reduce body weight and BMI while decreasing fat absorption from the diet.
8. Supports Gallbladder Function
CDCA helps contract the gallbladder to aid the flow of bile needed for digestion. This supports overall gallbladder function.
Applications of Chenodeoxycholic Acid
Chenodeoxycholic acid (CDCA) is one of the major bile acids synthesized in the liver from cholesterol. In addition to its roles in fat digestion and cholesterol regulation, CDCA has found applications across a diverse range of industries due to its unique chemical properties.
In the pharmaceutical industry, CDCA is used in the synthesis of ursodeoxycholic acid (UDCA), another bile acid with therapeutic benefits. UDCA is prescribed to treat gallstone dissolution, primary biliary cirrhosis, and other cholestatic liver diseases. The starting material for industrial scale production of UDCA is CDCA.
CDCA itself also has pharmaceutical applications for treating cerebrotendinous xanthomatosis (CTX), a rare metabolic disorder. As a drug active, CDCA helps alleviate the buildup of cholesterol and cholestanol deposits associated with CTX.
The ability of bile acids like CDCA to emulsify fats and oils makes them useful as surfactants in cosmetic formulations. CDCA can stabilize creams, lotions, and cleansing products while also solubilizing oil-soluble vitamins and botanical extracts. CDCA has less skin irritation compared to other surfactants.
As an emulsifier and solubilizer, CDCA allows mixing of water-soluble and oil-soluble ingredients in food products. It helps disperse flavors evenly and prevents separation in dressings, sauces, baked goods, ice cream, and other items. CDCA has been approved for use as a food additive in various countries.
CDCA’s ability to inhibit bacterial growth also makes it useful as a food preservative. It can extend the shelf-life of perishable foods and prevent spoilage.
In the nutrition industry, Chenodeoxycholic Acid Powder is offered as an individual supplement to provide the benefits of boosted fat absorption, cholesterol regulation, and gut health support. It helps address issues like fatty liver disease, high cholesterol, constipation, and gut dysbiosis.
CDCA is also added to multi-ingredient formulations for non-alcoholic fatty liver disease, weight management, gallbladder health, and other applications related to its physiological roles.
Bile acids improve fat digestibility and nutrient absorption in livestock animals. Adding CDCA to animal feeds for poultry, swine, cattle and fish has been shown to enhance growth rates and feed conversion efficiency. This leads to higher productivity in animal agriculture.
CDCA enhances enzymatic catalysis reactions involved in the conversion of oils and fats into biodiesel. It allows higher yields of biofuels to be derived from waste oils, plant oils, and animal fats. CDCA is more effective compared to other catalytic additives.
Packing And Shipping
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